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Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives

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Abstract

A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. Screening for anticancer activity against an array of human cancer cells revealed the superior activity of 2-(2,5-dimethoxyphenyl)-5-propylthio-1,3,4-oxadiazole. 2-(2,5-Dimethoxyphenyl)-5-butylthio-1,3,4-oxadiazole displayed excellent activity against breast cancer cell lines.

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Authors and Affiliations

  1. Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India

    N. Polkam, S. Malthum & J. S. Anireddy

  2. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana State, 500037, India

    U. Brahma & G. M. Naidu Vegi

Authors
  1. N. Polkam
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  2. S. Malthum
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  3. J. S. Anireddy
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  4. U. Brahma
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  5. G. M. Naidu Vegi
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Corresponding author

Correspondence to J. S. Anireddy.

Additional information

N. Polkam is thankful to University Grants Commission (UGC), New Delhi, Government of India for financial assistance in the form of a senior research fellowship. Authors N. Polkam and J. S. Anireddy are thankful to TEQIP-II for aiding improved laboratory facilities.

This work does not involve human participants and animal subjects.

The authors declare no competing interests.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 580–584, March, 2021.

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Polkam, N., Malthum, S., Anireddy, J.S. et al. Design, synthesis, and anticancer evaluation of new 1,3,4-oxadiazole thioether derivatives. Russ Chem Bull 70, 580–584 (2021). https://doi.org/10.1007/s11172-021-3128-0

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  • DOI: https://doi.org/10.1007/s11172-021-3128-0

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