Abstract
Cyclic acetals of ethylene glycol, cis-but-2-ene-1,4-diol and their dichlorocyclopropyl derivatives were synthesized. Compounds simultaneously containing the gem-dichlorocyclopropane and 1,3-dioxacycloalkane cycles are shown to exhibit cytotoxic activity against the HEK293, SH-SY5Y, HepG2, MCF-7, A549, and Jurkat cell lines. The obtained results open up prospects for further studies of antitumor activity of 2-(2,2-dichlorocyclopropyl)-2-ethyl-1,3-dioxolane.
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This work was carried out under financial support of the Council for Grants of the President of the Russian Federation (the Program of governmental support of young scientists PhD and DSc, Project No. MK-1689.2020.3) and within the framework of the state tasks of Institute of Biochemistry and Genetics of the Ufa Federal Research Centre of the Russian Academy of Sciences (Project No. AAAA-A16-116020350033-8).
This paper does not contain descriptions of studies on animals or humans.
The authors declare no competing interests.
Based on the materials of VI Interdisciplinary Conference “Molecular and Biological Aspects of Chemistry, Pharmaceuticals and Pharmacology” (September 27–30, 2020, Nizhny Novgorod, Russia).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 475–478, March, 2021.
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Raskil’dina, G.Z., Kuzmina, U.S., Dzhumaev, S.S. et al. Synthesis and cytotoxic properties of some cyclic acetals of diols and their dichlorocyclopropyl derivatives. Russ Chem Bull 70, 475–478 (2021). https://doi.org/10.1007/s11172-021-3111-9
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DOI: https://doi.org/10.1007/s11172-021-3111-9