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Modification of Fe3O4 magnetic nanoparticles with a GRGD peptide

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Russian Chemical Bulletin Aims and scope

Abstract

Derivatives of RGD peptides are promising vector molecules for targeting biomolecules and nanoparticles into tumor tissues and are used for the design of diagnostic agents. The immobilization of the glutaryl-containing derivative of Gly-l-Arg(Pbf)-Gly-l-Asp(OMe)2 (GRGD) tetrapeptide on Fe3O4 magnetic nanoparticles (MNPs) was studied. The results of thermogravimetric and elemental analysis, as well as IR spectroscopy, were used to estimate the amount of organic components at each stage of modification of MNPs.

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Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620108, Ekaterinburg, Russian Federation

    A. M. Demin, A. V. Vakhrushev, A. V. Mekhaev & V. P. Krasnov

  2. M. N. Mikheev Institute of Metal Physics, Ural Branch of the Russian Academy of Sciences, 18 ul. S. Kovalevskoi, 620990, Ekaterinburg, Russian Federation

    M. A. Uimin

  3. Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    V. P. Krasnov

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  1. A. M. Demin
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  2. A. V. Vakhrushev
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  3. A. V. Mekhaev
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  4. M. A. Uimin
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  5. V. P. Krasnov
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Corresponding author

Correspondence to A. M. Demin.

Additional information

This work was carried out within the framework of the state assignments (theme No. AAAA-A19-119011790130-3 and ttheme “Magnet” No. AAAA-A18-118020290129-5) using the equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds” (“SAOC”) of the I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences.

This work does not involve human participants and animal subjects.

The authors declare that there is no conflict of interest.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 449–456, March, 2021.

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Demin, A.M., Vakhrushev, A.V., Mekhaev, A.V. et al. Modification of Fe3O4 magnetic nanoparticles with a GRGD peptide. Russ Chem Bull 70, 449–456 (2021). https://doi.org/10.1007/s11172-021-3107-5

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  • DOI: https://doi.org/10.1007/s11172-021-3107-5

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