Abstract
Magnesium complexes based on sodium polygalacturonate and pectinate were prepared and characterized. The conditions of complex formation were optimized and the immunomodulatory activity of the complexes was studied in vivo for the first time. The pectin complexes with magnesium ions decrease the immunosuppressive effect of the cyclophosphamide cytostatic, associated with a decrease in the number of immune cells in the blood (leukopenia) after administration of cyclophosphamide, and promote restoration of the white blood cell count in blood and the ratio of their subpopulations, i.e., the complexes exhibit immunomodulatory properties.
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The authors are grateful to the personnel of the Collective Spectral Analytical Center for Physicochemical Studies of the Structure, Properties, and Composition of Compounds and Materials at the A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center, Kazan Scientific Center, Russian Academy of Sciences, for the performed investigations and contribution to the discussion of the results.
This study was financially supported by the Russian Foundation for Basic Research (Project No. 18-03-00310_a).
The authors declare that laboratory animals were kept and animal experiments were carried out in accordance with the rules stated in the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (Strasbourg, 1986) and in accordance with the principles of good laboratory practice of the Organization of Economic Cooperation and Development and the Russian Federation national standard “Principles of Good Laboratory Practice” (GOST R 53434-2009).
The authors declare no competing interest.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 433–443, March, 2021.
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Minzanova, S.T., Mironov, V.F., Khabibullina, A.V. et al. New metal complexes of citrus pectin with magnesium ions: synthesis, properties, and immunomodulatory activity. Russ Chem Bull 70, 433–443 (2021). https://doi.org/10.1007/s11172-021-3105-7
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DOI: https://doi.org/10.1007/s11172-021-3105-7