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Protolytic and potential antithyroid properties of thioglycolurils and fused azolo-1,2,4-triazines

Abstract

The protolytic properties and reactions with molecular iodine and blood serum proteins of 5,7-dimethyltetrahydro-1H-imidazo[4,5-e]-1,2,4-triazine-3,6(2H,4H)-dithione and (R)-1,3-dialkyl-4-[(2-hydroxybenzylidene)amino]-5-thioxohexahydroimidazo[4,5-d]imidazol-2(1H)-ones were studied. These compounds exhibit different chemical reactivities towards molecular iodine. The binding constants between these compounds and serum albumin attest to a considerable protein affinity of the compounds. The properties of the thiones make them promising as antithyroid agents.

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Correspondence to V. A. Ivolgina.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2215—2221, November, 2020.

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Ivolgina, V.A., Popov, L.D., Gazieva, G.A. et al. Protolytic and potential antithyroid properties of thioglycolurils and fused azolo-1,2,4-triazines. Russ Chem Bull 69, 2215–2221 (2020). https://doi.org/10.1007/s11172-020-3024-z

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  • DOI: https://doi.org/10.1007/s11172-020-3024-z

Key words

  • thioglycolurils
  • azolo-1,2,4-triazines
  • charge transfer complex
  • antithyroid activity