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Synthesis of 4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment and study of their inhibitory properties against protein kinases

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Abstract

Hybrid compounds based on 4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment were synthesized. Their inhibitory activity against protein kinases NPM1-ALK, ALK, EGFR[L858R][T790], EGFR[L858R], JAK2, and JAK3 was investigated. Compounds with inhibitory activity against protein kinase JAK3 at a level of 16.7 µmol L−1 were obtained.

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Authors and Affiliations

  1. Voronezh State University, 1 Universitetskaya pl., 394018, Voronezh, Russian Federation

    N. P. Novichikhina, A. S. Shestakov, A. Yu. Potapov, E. A. Kosheleva, G. V. Shatalov, V. N. Verezhnikov, D. Yu. Vandyshev, I. V. Ledeneva & Kh. S. Shikhaliev

Authors
  1. N. P. Novichikhina
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  2. A. S. Shestakov
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  3. A. Yu. Potapov
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  4. E. A. Kosheleva
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  5. G. V. Shatalov
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  6. V. N. Verezhnikov
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  7. D. Yu. Vandyshev
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  8. I. V. Ledeneva
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  9. Kh. S. Shikhaliev
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Corresponding author

Correspondence to Kh. S. Shikhaliev.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 18-74-10097).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0787–0792, April, 2020.

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Novichikhina, N.P., Shestakov, A.S., Potapov, A.Y. et al. Synthesis of 4H-pyrrolo[3,2,1-ij]quinoline-1,2-diones containing a piperazine fragment and study of their inhibitory properties against protein kinases. Russ Chem Bull 69, 787–792 (2020). https://doi.org/10.1007/s11172-020-2834-3

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  • DOI: https://doi.org/10.1007/s11172-020-2834-3

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