Abstract
A series of new chlorins bearing the phytyl moiety and different number of cationic groups were synthesized based on pheophytin a. A comparative evaluation of dark cytotoxicity and photodynamic activity of the synthesized compounds was performed using mature mammalian erythrocytes. Both dark and photoinduced hemolytic activities of the synthesized compounds grow with increasing the number of the cationic group in the molecule.
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This work was financially supported by the Ural Branch of the Russian Academy of Sciences (Project No. 18-3-3-27; synthesis of the compounds) and the Ministry of Science and Higher Education of the Russian Federation (Project No. AAAA-A18-118011120004-5; evaluation of biological activity).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0742–0750, April, 2020.
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Khudyaeva, I.S., Shevchenko, O.G. & Belykh, D.V. New membranotropic cationic chlorins derived from pheophytin a: synthesis and evaluation of photodynamic activity. Russ Chem Bull 69, 742–750 (2020). https://doi.org/10.1007/s11172-020-2827-2
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DOI: https://doi.org/10.1007/s11172-020-2827-2