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Synthesis and antibacterial activity of new dimeric pyridinium chlorides based on 2,2-bis(hydroxymethyl)propane-1,3-diyl spacer

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Abstract

New bispyridinium dichlorides based on 2,2-bis(hydroxymethyl)propane-1,3-diyl spacer were synthesized from pentaerythritol, 4-aminopyridine, and carboxylic acids. The resulting biocides possess a high antibacterial effect. The minimal inhibitory concentration (MIC) of these compounds against pathogenic bacteria, namely, gram-positive Methicillin-resistant Staphylococcus aureus (strain ATCC 25923) and gram-negative Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853), was established. The influence of the alkyl substituent length in salts on their microbiological activity was studied.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. N. Vereshchagin, K. A. Karpenko & M. P. Egorov

Authors
  1. A. N. Vereshchagin
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  2. K. A. Karpenko
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  3. M. P. Egorov
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Corresponding author

Correspondence to A. N. Vereshchagin.

Additional information

This work was financially supported by the President of the Russian Federation Council for Grants (Program for State Support of Young Scientists of Russia, Grant MD-545.2019.3).

Based on the Materials of the IV Russian Conference on Medical Chemistry with International Participation (June 9–14, 2019, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0620—0623, March, 2020.

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Vereshchagin, A.N., Karpenko, K.A. & Egorov, M.P. Synthesis and antibacterial activity of new dimeric pyridinium chlorides based on 2,2-bis(hydroxymethyl)propane-1,3-diyl spacer. Russ Chem Bull 69, 620–623 (2020). https://doi.org/10.1007/s11172-020-2808-5

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  • DOI: https://doi.org/10.1007/s11172-020-2808-5

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