Skip to main content
SpringerLink
Log in

Water-soluble proteins as an excipient for drug administration by inhalation

  • Full Articles
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

Microspherical particles of composite drugs based on lysozyme and albumin, which can be used in inhalation administration, were prepared by spray drying. The composition of the complexes was determined using experimental and theoretical methods. The use of the protein matrix makes it possible to increase the dissolution rate of the drug in water. The obtained results can be useful for the development of new drug dosage forms with increased bioavailability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. C. Neu, T. D. Gootz, in Medical Microbiology, Ed. S. Baron, The University of Texas Medical Branch at Galveston, Galveston, 1996.

    Google Scholar 

  2. K. C. van Meter, R. J. Hubert, Microbiology for the Healthcare Professional, Elsevier, Mosby, St. Louis, USA, 2016.

    Google Scholar 

  3. A. Ronald, Disease-a-Month, 2003, 49, 2, 71.

    Article  Google Scholar 

  4. J. S. Patton, C. S. Fishburn, J. G. Weers, Proc. Am. Thoracic Soc., 2004, 1, 338.

    Article  CAS  Google Scholar 

  5. A. Boldyrev, M. Ziganshin, A. Osipov, T. Mukhametzyanov, N. Lyadov, A. Klimovitskii, A. Gerasimov, BioNanoScience, 2019, 9, 131.

    Article  Google Scholar 

  6. D. Verma, N. Gulati, S. Kaul, S. Mukherjee, U. Nagaich, J. Pharmaceutics, 2018, 9285854.

    Google Scholar 

  7. D. Jao, Y. Xue, J. Medina, X. Hu, Materials (Basel), 2017, 10, 517.

    Article  Google Scholar 

  8. Y. Zhang, T. Sun, C. Jiang, Acta Pharmaceutica Sinica B, 2018, 8, 34.

    Article  Google Scholar 

  9. F. Kratz, J. Control. Release, 2008, 132, 171.

    Article  CAS  Google Scholar 

  10. R._F. G. Haverdings, M. Haas, A. R. Greupink, P. A. M. de Vries, F. Moolenaar, D. de Zeeuw, D. K. F. Meijer, Renal Failure, 2001, 23, 397.

    Article  CAS  Google Scholar 

  11. K.-J. Kim, A. B. Malik, Am. J. Physiol.-Lung Cell. Mol. Physiol., 2003, 284, L247.

    Article  CAS  Google Scholar 

  12. B. Masschalck, C. W. Michiels, Crit. Rev. Microbiol., 2003, 29, 191.

    Article  CAS  Google Scholar 

  13. A. Galukhin, M. A. Khelkhal, A. Gerasimov, T. Biktagirov, M. Gafurov, A. Rodionov, S. Orlinskii, Energy Fuels, 2016, 30, 7731.

    Article  CAS  Google Scholar 

  14. A. V. Gerasimov, M. A. Ziganshin, V. V. Gorbatchuk, World Appl. Sci. J., 2013, 24, 920.

    CAS  Google Scholar 

  15. M. A. Ziganshin, A. A. Bikmukhametova, A. V. Gerasimov, V. V. Gorbatchuk, S. A. Ziganshina, A. A. Bukharaev, Prot. Met. Phys. Chem., 2014, 50, 49.

    Article  CAS  Google Scholar 

  16. M. A. Ziganshin, A. V. Gerasimov, S. A. Ziganshina, N. S. Gubina, G. R. Abdullina, A. E. Klimovitskii, V. V. Gorbatchuk, A. A. Bukharaev, J. Therm. Anal. Calorim., 2016, 125, 905.

    Article  CAS  Google Scholar 

  17. T. Jarunglumlert, K. Nakagawa, Dry Technol., 2013, 31, 1459.

    Article  CAS  Google Scholar 

  18. U. Bhardwaj, D. J. Burgess, Int. J. Pharm., 2010, 388, 287.

    Article  CAS  Google Scholar 

  19. O. Trott, A. J. Olson, J. Comput. Chem., 2010, 31, 455.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. E. F. Pettersen, T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, T. E. Ferrin, J. Comput. Chem., 2004, 13, 1605.

    Article  Google Scholar 

  21. https://www.rcsb.org.

  22. N. J. Babu, A. Nangia, Cryst. Growth Des., 2011, 11, 2662.

    Article  CAS  Google Scholar 

  23. A. V. Gerasimov, M. A. Ziganshin, V. V. Gorbatchuk, L. S. Usmanova, Int. J. Pharm. Pharm. Sci., 2014, 6, 372.

    Google Scholar 

  24. G. P. Johari, S. Ram, G. Astl, E. Mayer, J. Non-Cryst. Solids, 1990, 116, 282.

    Article  CAS  Google Scholar 

  25. A. Topacli, B. Kesimli, Spectrosc. Lett., 2001, 34, 513.

    Article  CAS  Google Scholar 

  26. W. C. Hinds, Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles, John Wiley & Sons, New York, 1999.

    Google Scholar 

  27. D. E. Potts, D. C. Levin, S. A. Sahn, Chest, 1976, 70, 328.

    Article  CAS  Google Scholar 

  28. M. C. Houston, Am. J. Surgery, 1987, 154, 333.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute, 18 ul. Kremlevskaya, 420008, Kazan, Russian Federation

    A. E. Boldyrev, M. A. Ziganshin, A. E. Klimovitskii & A. V. Gerasimov

  2. E. K. Zavoisky Physical Technical Institute, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences,”, 10/7 Sibirsky tract, 420029, Kazan, Russian Federation

    N. M. Lyadov

Authors
  1. A. E. Boldyrev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. A. Ziganshin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. M. Lyadov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. E. Klimovitskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Gerasimov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Gerasimov.

Additional information

This work was financially supported by the Russian Foundation for Basic Research (Project No. 18-015-00267). The SEM measurements were carried out by N. M. Lyadov in the framework of the state task of the Ministry of Science and Higher Education of the Russian Federation (theme No. AAAA-A18_118041760011-2).

Based on the materials of the International Markovnikov Congress on Organic Chemistry (June 21–28, 2019, Moscow-Kazan, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0608—0614, March, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boldyrev, A.E., Ziganshin, M.A., Lyadov, N.M. et al. Water-soluble proteins as an excipient for drug administration by inhalation. Russ Chem Bull 69, 608–614 (2020). https://doi.org/10.1007/s11172-020-2806-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-020-2806-7

Keywords

Search

Navigation