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Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides

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Abstract

New derivatives of tetrapeptides GRGD (Gly-Arg(Pbf)-Gly-Asp(OMe)-OMe) and KRGD (Boc-Lys-Arg(Pbf)-Gly-Asp(OMe)-OMe) containing a glutaric acid fragment as a linker were synthesized. The linker provides the possibility for binding these derivatives to other biologically active molecules or nanoparticles.

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Author information

Authors and Affiliations

  1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22 ul. S. Kovalevskoi, 620990, Ekaterinburg, Russian Federation

    A. M. Demin, A. V. Vakhrushev, A. A. Tumashov & V. P. Krasnov

  2. Institute of Natural Sciences and Mathematics, Ural Federal University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    A. A. Tumashov

Authors
  1. A. M. Demin
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  2. A. V. Vakhrushev
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  3. A. A. Tumashov
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  4. V. P. Krasnov
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Corresponding author

Correspondence to A. M. Demin.

Additional information

The authors are grateful to M. I. Kodess for recording the NMR spectra, I. N. Ganebnykh for recording the mass spectra, and E. N. Chulakov for isolation of compounds by preparative HPLC.

The work was performed in the framework of the Russian state assignment (Theme No. AAAA-A19-119011790130-3) using equipment of the Centre for Joint Use “Spectroscopy and Analysis of Organic Compounds” at the I. Ya. Postovsky Institute of Organic Synthesis of the Russian Academy of Sciences (Ural Branch).

Based on the materials of the 4th Russian Conference on Medical Chemistry with International participation (June 9–14, 2019, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2316–2324, December, 2019.

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Demin, A.M., Vakhrushev, A.V., Tumashov, A.A. et al. Synthesis of glutaryl-containing derivatives of GRGD and KRGD peptides. Russ Chem Bull 68, 2316–2324 (2019). https://doi.org/10.1007/s11172-019-2705-y

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  • DOI: https://doi.org/10.1007/s11172-019-2705-y

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