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Methyl N-(carbazolyl)acetyl-2-aminotetrahydrobenzothiophene-3-carboxylates as modulators of NMDA receptors

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Abstract

Methyl N-(carbazolyl)acetyl-2-aminotetrahydrothiophene-3-carboxylates were synthesized by alkylation of carbazoles with the corresponding chloroacetylamides of 2-aminotiophenes. The radioligand binding method showed the presence of the modulating effect of the synthesized compounds on the neuronal NMDA receptors.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, A. V. Gabrel’yan & V. V. Grigoriev

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  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. A. V. Gabrel’yan
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  4. V. V. Grigoriev
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Correspondence to A. Yu. Aksinenko.

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Sokolov, V.B., Aksinenko, A.Y., Gabrel’yan, A.V. et al. Methyl N-(carbazolyl)acetyl-2-aminotetrahydrobenzothiophene-3-carboxylates as modulators of NMDA receptors. Russ Chem Bull 68, 1629–1632 (2019). https://doi.org/10.1007/s11172-019-2602-4

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  • DOI: https://doi.org/10.1007/s11172-019-2602-4

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