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Avermectin B1 5-O-mono-and 4″,5-O, O-bis-derivatization with ethyl succinoyl moiety

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Abstract

Reaction of avermectin B1 with succinic acid monoethyl ester chloride under catalysis of 2,6-lutidine provided hitherto unknown 5-O-mono- and 4″,5-O, O-bis-derivatives with ethyl succinoyl moiety that are potential antiparasitics.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. V. Lyubeshkin, M. A. Shchetinina, E. I. Chernoburova & I. V. Zavarzin

  2. K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, 23 ul. Akad. Skryabina, 109472, Moscow, Russian Federation

    M. Kh. Dzhafarov & F. I. Vasilevich

Authors
  1. A. V. Lyubeshkin
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  2. M. A. Shchetinina
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  3. E. I. Chernoburova
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  4. M. Kh. Dzhafarov
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  5. F. I. Vasilevich
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  6. I. V. Zavarzin
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Corresponding author

Correspondence to I. V. Zavarzin.

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Lyubeshkin, A.V., Shchetinina, M.A., Chernoburova, E.I. et al. Avermectin B1 5-O-mono-and 4″,5-O, O-bis-derivatization with ethyl succinoyl moiety. Russ Chem Bull 68, 644–647 (2019). https://doi.org/10.1007/s11172-019-2469-4

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  • DOI: https://doi.org/10.1007/s11172-019-2469-4

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