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Reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products

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Abstract

The reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides (hetaryl is 2-pyridyl, 2-azolyls, benzo[d]thiazol-2-yl) with hydroxylamine yielded 4-aryl-N-hetaryl-2-hydroxyimino-4-oxobutanamides and 5-aryl-N-hetarylisoxazole-3-carboxamides. The products were searched for representatives with high antimicrobial and anti-inflammatory activities and low acute toxicity. A structure—pharmacological activity relationship of the prepared compounds was established.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 2 ul. Polevaya, 614990, Perm, Russian Federation

    N. A. Pulina, F. V. Sobin, T. A. Yushkova & V. V. Novikova

Authors
  1. N. A. Pulina
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  2. F. V. Sobin
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  3. T. A. Yushkova
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  4. V. V. Novikova
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Correspondence to N. A. Pulina.

Additional information

Based on the materials of the V All-Russian Organic Chemistry Conference (ROCC-V) (September 10–14, 2018, Vladikavkaz, Russia).

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Pulina, N.A., Sobin, F.V., Yushkova, T.A. et al. Reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products. Russ Chem Bull 68, 628–633 (2019). https://doi.org/10.1007/s11172-019-2466-7

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  • DOI: https://doi.org/10.1007/s11172-019-2466-7

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