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Acyl derivatives of ivermectin 5-oxime with antifungal activity

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Abstract

Acylation of ivermectin 5-oxime was first studied. Procedures for selective acylation of ivermectin 5-oxime either selectively at 5-oxime group or at both 5-oxime group and 4″-hydroxy group to give, respectively, mono- and diacyl derivatives were developed. The synthesized compounds exhibit antifungal activity.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    E. I. Chernoburova, M. A. Shchetinina, M. Kh. Dzhafarov, V. B. Krylov & I. V. Zavarzin

Authors
  1. E. I. Chernoburova
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  2. M. A. Shchetinina
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  3. M. Kh. Dzhafarov
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  4. V. B. Krylov
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  5. I. V. Zavarzin
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Corresponding author

Correspondence to I. V. Zavarzin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0438–0444, February, 2019.

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Chernoburova, E.I., Shchetinina, M.A., Dzhafarov, M.K. et al. Acyl derivatives of ivermectin 5-oxime with antifungal activity. Russ Chem Bull 68, 438–444 (2019). https://doi.org/10.1007/s11172-019-2405-7

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  • DOI: https://doi.org/10.1007/s11172-019-2405-7

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