Synthesis and physicochemical properties of the pectin complexes with Xymedon

Abstract

The formation of stable complexes of pectin polysaccharides with 1-(2-hydroxyethyl)-4,6- dimethyl-1,2-dihydropyrimidin-2-one (Xymedon drug) was shown by UV and IR spectro scopy, dynamic light scattering, and polarimetry. The stoichiometry of the complexes was determined, and their synthesis conditions were optimized. Specific features of the thermal decomposition of pectin and synthesized complexes with Xymedon were studied by the TG/DSC method. The results obtained allow one to substantially extend ranges of using Xymedon in medicine.

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Correspondence to S. T. Minzanova.

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Dedicated to Academician of the Russian Academy of Sciences A. I. Konovalov on the occasion of his 85th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0405–0410, February, 2019.

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Minzanova, S.T., Mironov, V.F., Khabibullina, A.V. et al. Synthesis and physicochemical properties of the pectin complexes with Xymedon. Russ Chem Bull 68, 405–410 (2019). https://doi.org/10.1007/s11172-019-2400-z

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Key words

  • pectin
  • Xymedon
  • complexation