Synthesis of new trichloromethyl- and alkoxy-substituted pyrido[2,3-d]pyrimidine derivatives

Abstract

A series of new trichloromethyl- and alkoxy-substituted pyrido[2,3-d]pyrimidine derivatives were obtained from trichloromethyl-substituted pyrimidines with vicinal amino and acyl groups synthesized based on the reaction of trichloroacetonitrile with β-diketone diaminomethylidene derivatives.

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Correspondence to S. V. Baranin.

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Dedicated to Corresponding Member of the Russian Academy of Sciences G. I. Nikishin on the occasion of his 90th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0365–0373, February, 2019.

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Komkov, A.V., Potapova, T.V., Zuev, M.I. et al. Synthesis of new trichloromethyl- and alkoxy-substituted pyrido[2,3-d]pyrimidine derivatives. Russ Chem Bull 68, 365–373 (2019). https://doi.org/10.1007/s11172-019-2394-6

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Key words

  • trichloroacetonitlile
  • α,α-diacyl ketene aminals
  • N-acyl-α-acetyl ketene aminals
  • amidines
  • pyrimidines
  • pyrido[2,3-d]pyrimidines