The reaction of amidoximes with carboxylic acids or their esters under high-pressure conditions

Abstract

3,5-Disubstituted 1,2,4-oxadiazoles were synthesized by the reaction of amidoximes with carboxylic acids or their esters under high-pressure conditions (10 kbar). The reaction proceeds without the use of other reagents or catalysts. Both aliphatic and aromatic carboxylic acids undergo this reaction. The obtained 1,2,4-oxadiazoles possess high fungicidal activity.

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Correspondence to I. V. Zavarzin.

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Dedicated to Corresponding Member of the Russian Academy of Sciences G. I. Nikishin on occasion of his 90th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0347–0350, February, 2019.

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Baikov, S.V., Stashina, G.A., Chernoburova, E.I. et al. The reaction of amidoximes with carboxylic acids or their esters under high-pressure conditions. Russ Chem Bull 68, 347–350 (2019). https://doi.org/10.1007/s11172-019-2391-9

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Key words

  • amidoximes
  • carboxylic acids
  • esters
  • 1,2,4-oxadiazoles
  • high pressure
  • fungicidal activity