Aggregation behavior and solubilization properties of 3-hydroxypiperidinium surfactants

Abstract

Systematic data on the aggregation behavior of novel 3-hydroxypiperidinium surfactants in aqueous solutions were obtained. The ability of the surfactants to solubilize hydrophobic compounds, including the Orange OT dye and biologically active flavonoid quercetin, was characterized. The maximally achieved limiting content of these substances in micellar solutions of 3-hydroxypiperidinium surfactants is by two to three times higher than that in solutions of their non-functionalized analogs. The solubility of quercetin depends on the pH of the medium, and the highest effect observed on going from water to micellar solutions of the studied surfactants reaches two orders of magnitude.

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Correspondence to A. B. Mirgorodskaya.

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Dedicated to Academician of the Russian Academy of Sciences A. I. Konovalov on the occasion of his 85th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0328–0333, February, 2019.

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Mirgorodskaya, A.B., Kushnazarova, R.A., Lukashenko, S.S. et al. Aggregation behavior and solubilization properties of 3-hydroxypiperidinium surfactants. Russ Chem Bull 68, 328–333 (2019). https://doi.org/10.1007/s11172-019-2388-4

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Key words

  • surfactants
  • aggregation
  • solubilization
  • drugs