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Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

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Abstract

Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.

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Authors and Affiliations

  1. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Build. 4, 31 Leninsky prosp., 119071, Moscow, Russian Federation

    G. S. Tsebrikova, V. P. Solov´ev, Z. A. Kudryashova, V. E. Baulin & A. Yu. Tsivadze

  2. Russian Technological University, Lomonosov Moscow State University of Fine Chemical Technologies, 78 prosp. Vernadskogo, 119454, Moscow, Russian Federation

    R. T. Barsamian & Z. A. Kudryashova

  3. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. E. Baulin

  4. School of Materials Science and Engineering, Harbin Institute of Technology, 92 West Dashi st., 150001, Harbin, China

    Y. J. Wang

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  1. G. S. Tsebrikova
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  2. R. T. Barsamian
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  3. V. P. Solov´ev
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  4. Z. A. Kudryashova
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  5. V. E. Baulin
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  6. Y. J. Wang
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  7. A. Yu. Tsivadze
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Correspondence to G. S. Tsebrikova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2184–2187, December, 2018.

Based on the materials of the VII International Conference on Physical Chemistry of Crown Compounds, Porphyrins and Phthalocyanines (September 9–14, 2018, Tuapse, Russia).

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Tsebrikova, G.S., Barsamian, R.T., Solov´ev, V.P. et al. Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid). Russ Chem Bull 67, 2184–2187 (2018). https://doi.org/10.1007/s11172-018-2352-8

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  • DOI: https://doi.org/10.1007/s11172-018-2352-8

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