Abstract
The interaction of calf thymus DNA (CT DNA) with trans-[PtCl2L2] and trans-[PdCl2L2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = But, CH2CH2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (Kb) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•105 mol L–1 for the PdII complexes and (7.82–13.30)•105 mol L–1 for and the PtII complexes, respectively. The Kb values, as well as negative values of ΔGb (–(31.7–34.9) kJ mol–1) indicate the effective binding between the studied complexes and CT DNA.
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Based on the materials of the XXVII International Chugayev Conference on Coordination Chemistry (October 2–6, 2017; Nizhny Novgorod, Russia).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1312–1315, July, 2018.
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Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1
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DOI: https://doi.org/10.1007/s11172-018-2217-1