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Complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical

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Abstract

The cytotoxicity of complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl) benzamide) against the K-562 cell line (chronic myeloid leukemia) was considered in comparison with the cells of healthy donors. The 69mZnLigCl2 complex was obtained and characterized by TLC and autoradiography methods. The kinetics of zinc sorption on hydroxyapatite was studied.

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Authors and Affiliations

  1. Chemical Department, M. V. Lomonosov Moscow State University, Building 3, 1 Leninskie Gory, 119992, Moscow, Russian Federation, Russia

    M. A. Orlova, T. P. Trofimova, A. P. Orlov, I. A. Ivanov, A. V. Severin, G. Yu. Aleshin, A. N. Vasiliev & S. N. Kalmykov

  2. Dmitry Rogachev National Medical Scientific Center of Pediatric Hematology, Oncology, and Immunology, 1 ul. Samory Mashela, 117997, Moscow, Russian Federation, Russia

    M. A. Orlova

  3. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation, Russia

    T. P. Trofimova

  4. D. V. Skobel’tsyn Research Institute of Nuclear Physics, M. V. Lomonosov Moscow State University, Building 2, 1 Leninskie Gory, 119992, Moscow, Russian Federation, Russia

    S. S. Belyshev

  5. National Research Center “Kurchatov Institute,”, 1 pl. Akad. Kurchatova, 123098, Moscow, Russian Federation, Russia

    S. N. Kalmykov

Authors
  1. M. A. Orlova
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  2. T. P. Trofimova
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  3. A. P. Orlov
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  4. I. A. Ivanov
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  5. A. V. Severin
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  6. G. Yu. Aleshin
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  7. S. S. Belyshev
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  8. A. N. Vasiliev
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  9. S. N. Kalmykov
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Corresponding author

Correspondence to M. A. Orlova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0774–0778, April, 2018.

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Orlova, M.A., Trofimova, T.P., Orlov, A.P. et al. Complex 69mZnLigCl2 (Lig is N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide) as a potential radiopharmaceutical. Russ Chem Bull 67, 774–778 (2018). https://doi.org/10.1007/s11172-018-2136-1

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  • DOI: https://doi.org/10.1007/s11172-018-2136-1

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