Russian Chemical Bulletin

, Volume 66, Issue 11, pp 2190–2193 | Cite as

A case of non-monotonous influence of pressure on enantioselectivity in supercritical fluid chromatography

  • O. I. Pokrovskiy
  • M. O. Kostenko
  • V. V. Lunin
Brief Communication


non-monotonous dependence of selectivity coefficient on pressure in the enantioseparation of salbutamol sulfate by supercritical fluid chromatography was discovered. When increasing the isothermal pressure of the mobile phase in the interval 100—200 bar at a temperature of 20 °С, the selectivity coefficient of separation of salbutamol enantiomers first increased, then decreased, followed by another increase. Such a behavior is atypical and determines the expediency of using pressure to control selectivity in this kind of chromatography.

Key words

supercritical fluid chromatography selectivity enantiomers pressure non-monotonous behavior 


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • O. I. Pokrovskiy
    • 1
  • M. O. Kostenko
    • 2
  • V. V. Lunin
    • 1
    • 2
  1. 1.N. S. Kurnakov Institute of General and Inorganic ChemistryRussian Academy of SciencesMoscowRussian Federation
  2. 2.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation

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