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Russian Chemical Bulletin

, Volume 66, Issue 11, pp 2152–2156 | Cite as

Cryochemical synthesis and antibacterial activity of hybrid nanocomposites based on dioxidine containing Ag and Cu nanoparticles incorporated in biopolymer cryostructurates

  • O. I. Vernaya
  • V. P. Shabatin
  • A. V. Nuzhdina
  • N. D. Zvukova
  • D. I. Khvatov
  • A. M. Semenov
  • V. I. Lozinskii
  • T. I. Shabatina
  • M. Ya. Melnikov
Full Article
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Abstract

Cryochemical synthesis of hybrid nanocomposites based on the antibacterial drug, dioxidine, and metals (Ag, Cu) was performed. According to the data of H1 NMR, UV, and IR spectroscopy, low-temperature argon sorption, and transmission electron microscopy, met-als in these systems exist as Ag nanoparticles (with dimensions of 2—30 nm) or Cu nanoparti-cles (10—40 nm) involved in the bigger-sized particles of dioxidine with dimensions of 50—350 nm. These hybrid nanocomposites show the enhanced antibacterial activity towards the microbial cells Escherichia coli 52, Staphylococcus aureus 144, Mycobacterium cyaneum 98. The as-prepared drug nanocomposites are incorporated into spongy alginate cryostructurates. The feasibility of drug release from the biopolymer alginate carrier is proved and the related antibacterial activity is demonstrated.

Key words

cryochemical synthesis hybrid nanocomposites dioxidine silver and copper nanoparticles alginate cryostructurates antibacterial activity 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • O. I. Vernaya
    • 1
  • V. P. Shabatin
    • 1
  • A. V. Nuzhdina
    • 1
  • N. D. Zvukova
    • 3
  • D. I. Khvatov
    • 2
  • A. M. Semenov
    • 2
  • V. I. Lozinskii
    • 3
  • T. I. Shabatina
    • 1
  • M. Ya. Melnikov
    • 1
  1. 1.Department of ChemistryM. V. Lomonosov Moscow State UniversityMoscowRussian Federation
  2. 2.Department of BiologyM. V. Lomonosov Moscow State UniversityMoscowRussian Federation
  3. 3.A. N. Nesmeyanov Institute of Organoelement CompoundRussian Academy of SciencesMoscowRussian Federation

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