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Biological activity of some sulfur- and selenium-containing spiro compounds

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Abstract

Cytotoxicity to K-562 leukemia cell line of two spiro compounds containing selenium or sulfur atom in their structure were compared. 4-Fluorophenyl-(1-thia-3-azaspiro[5.5]undec-2-en-2-yl]amine hydrobromide was synthesized and characterized for the first time. It was found that the introduction of a sulfur atom is more promising for this biological model, since it leads to a 3-fold increase in the therapeutic index in the case of the sulfur-containing compound.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi pr-d, 142432, Chernogolovka, Moscow Region, Russian Federation

    A. N. Proshin

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    M. A. Orlova & T. P. Trofimova

  3. Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology, I ul. Samory Mashela, 117997, Moscow, Russian Federation

    M. A. Orlova & T. P. Trofimova

Authors
  1. A. N. Proshin
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  2. M. A. Orlova
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  3. T. P. Trofimova
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Corresponding author

Correspondence to M. A. Orlova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1931—1933, October, 2017.

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Proshin, A.N., Orlova, M.A. & Trofimova, T.P. Biological activity of some sulfur- and selenium-containing spiro compounds. Russ Chem Bull 66, 1931–1933 (2017). https://doi.org/10.1007/s11172-017-1968-4

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  • DOI: https://doi.org/10.1007/s11172-017-1968-4

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