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Increasing selective bilirubin removal by hypercross-linked polystyrene hemosorbents

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Abstract

A high efficiency of indirect bilirubin removal from systems modelling blood plasma by polymers of various structures and, most importantly, by hemocompatible hypercross-linked polystyrenes such as Styrosorb is demonstrated. Approaches to increasing the selectivity of hypercross-linked polystyrenes for the removal of bilirubin from biological fluids with a high serum albumin content were found, making them promising materials for the manufacture of hemosorption columns effective for hepatitis therapy and other conditions caused by a high bilirubin content in the blood plasma.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    L. A. Pavlova, A. V. Pastukhov & V. A. Davankov

  2. JSC Advanced Medical Technologies, 4 Lukov per., 107045, Moscow, Russian Federation

    M. N. Kopitsyna, A. S. Morozov, I. V. Bessonov, S. E. Smirnova & D. A. Bagnyukova

Authors
  1. L. A. Pavlova
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  2. A. V. Pastukhov
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  3. M. N. Kopitsyna
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  4. A. S. Morozov
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  5. I. V. Bessonov
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  6. S. E. Smirnova
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  7. D. A. Bagnyukova
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  8. V. A. Davankov
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Correspondence to L. A. Pavlova.

Additional information

Based on the Materials of the XX Mendeleev Congress on General and Applied Chemistry (September 26—30, 2016, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1891—1896, October, 2017.

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Pavlova, L.A., Pastukhov, A.V., Kopitsyna, M.N. et al. Increasing selective bilirubin removal by hypercross-linked polystyrene hemosorbents. Russ Chem Bull 66, 1891–1896 (2017). https://doi.org/10.1007/s11172-017-1963-9

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  • DOI: https://doi.org/10.1007/s11172-017-1963-9

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