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Structure—hemolytic activity relationship in isobornylphenol derivatives

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Abstract

A structure — hemolytic activity relationship in isobornylphenol derivatives was analysed. The morphological transformation of erythrocytes under the influence of some representatives of this class of compounds was demonstrated by scanning electron microscopy. The hemolytic activity of the test compounds can vary within wide limits, depending on the structure and position of substituents determining the nature of the interaction of the compound with the cell membrane.

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Authors and Affiliations

  1. Institute of Biology, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation

    O. G. Shevchenko & S. N. Plyusnina

  2. Institute of Chemistry, Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomaiskaya, 167000, Syktyvkar, Russian Federation

    E. V. Buravlev, I. Yu. Chukicheva, I. V. Fedorova, O. V. Shchukina & A. V. Kutchin

Authors
  1. O. G. Shevchenko
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  2. S. N. Plyusnina
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  3. E. V. Buravlev
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  4. I. Yu. Chukicheva
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  5. I. V. Fedorova
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  6. O. V. Shchukina
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  7. A. V. Kutchin
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Correspondence to I. Yu. Chukicheva.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1881—1890, October, 2017.

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Shevchenko, O.G., Plyusnina, S.N., Buravlev, E.V. et al. Structure—hemolytic activity relationship in isobornylphenol derivatives. Russ Chem Bull 66, 1881–1890 (2017). https://doi.org/10.1007/s11172-017-1962-x

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  • DOI: https://doi.org/10.1007/s11172-017-1962-x

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