Abstract
The corrective action of 1,3,4-6Н-thiadiazines in experimental diabetes mellitus was studied. The structure—activity relationship model for this series of compounds was proposed using the multiple linear regression method.
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Oslozhneniya sakharnogo diabeta: lechenie i profilaktika [Complications of Diabetes Mellitus: Treatment and Prevention], Eds I. I. Dedov and M. V. Shestakova, Meditsinskoe informatsionnoe agentstvo, Moscow, 2017, 744 pp. (in Russian).
Mishen´-orientirovannyi poisk antidiabeticheskikh sredstv [Target-Oriented Search for Antidiabetic Drugs], Eds V. I. Petrov and A. A. Spasov, Izd-vo VolgGMU, Volgograd, 2016, 232 pp. (in Russian).
L. P. Sidorova, T. A. Tseitler, N. M. Perova, V. V. Emel´yanov, E. A. Savateeva, N. E. Maksimova, N. N. Mochul´skaya, V. A. Chereshnev, O. N. Chupakhin, Pharm. Chem. J., 2015, 49,501.
L. P. Sidorova, T. A. Tseitler, V. V. Emel´yanov, E. A. Savateeva, N. E. Maksimova, N. N. Mochul´skaya, V. A. Chereshnev, O. N. Chupakhin, Pharm. Chem. J., 2017, 51,9.
V. V. Emelianov, E. A. Savateeva, L. P. Sidorova, T. A. Tseitler, T. S. Bulavintseva, I. F. Gette, I. G. Danilova, N. E. Maksimova, N. N. Mochul´skaya, O. N. Chupakhin, V. A. Chereshnev, Ros. Immunolog. Zh. [Russ. J. Immunology], 2015, 9 (18), No. 2 (1), 487 (in Russian).
V. V. Emelianov, E. A. Savateeva, L. P. Sidorova, T. A. Tseitler, I. F. Gette, T. S. Bulavintseva, S. E. Smirnykh, N. E. Maksimova, N. N. Mochulskaya, O. N. Chupakhin, V. A. Chereshnev, Bull. Exp. Biol. Med., 2016, 162,35.
A. P. Sarapultsev, O. N. Chupakhin, P. A. Sarapultsev, L. P. Sidorova, T. A. Tseitler, Pharmaceuticals, 2016, 9 (2), 27; doi: 10.3390/ph9020027.
Pat. RF 2157210; Byul. Izobret. [Inventor Bull.], 2010, No. 28 (in Russian).
Pat. RF 2456284; Byul. Izobret. [Inventor Bull.], 2012, No. 20 (in Russian).
O. N. Chupakhin, L. P. Sidorova, N. M. Perova, V. L. Rusinov, T. M. Vasil´eva, V. A. Makarov, Pharm. Chem. J., 2011, 45,270.
Molinspiration. Calculation of Molecular Properties and Bioactivity Score; http://www.molinspiration.com/cgi-bin/properties.
N. R. Draper, H. Smith, Applied Regression Analysis, 2nd ed., Wiley, New York, 1981, 709 pp.
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Based on the Materials of the XX Mendeleev Congress on General and Applied Chemistry (September 26—30, 2016, Ekaterinburg, Russia).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1873—1875, October, 2017.
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Emelianov, V.V., Ivanov, A.V., Savateeva, E.A. et al. Structure—activity relationship in the series of 1,3,4-6Н-thiadiazines correcting metabolic disorders in experimental diabetes mellitus. Russ Chem Bull 66, 1873–1875 (2017). https://doi.org/10.1007/s11172-017-1960-z
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DOI: https://doi.org/10.1007/s11172-017-1960-z