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Zinc-containing derivatives of 2-aminopyrimidine

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Abstract

A platform containing three anticancer components is proposed. The components are a radioactive 69mZn isotope and zinc complexes, where both zinc and ligand exhibit anticancer properties. Two zinc-containing complexes, namely (2-AP)2ZnCl2 and (2-AP)2Zn(Sal)2 (AP is 2-aminopyrimidine, Sal is salicylate) were synthesized and characterized. Their cytotoxicity with respect to some leukemia cell lines is demonstrated. Their stability in physiological solution and percentage of apoptosis (by flow cytometry) are investigated. Stable complexes of compounds with the isotope 69mZn were characterized by TLC and autoradiography.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, Build. 3, 1 Leninskie Gory, 119991, Moscow, Russian Federation

    A. P. Orlov, T. P. Trofimova & M. A. Orlova

  2. Dmitry Rogachev National Scientific-Clinical Center of Pediatric Hematology, Oncology, and Immunology, 1 ul. Samory Mashela, 117997, Moscow, Russian Federation

    T. P. Trofimova, E. Yu. Osipova & M. A. Orlova

  3. Institute of Physiological Active Compounds, Russian Academy of Sciences, 1 Severnyi pr-d, 142432, Chernogolovka, Moscow Region, Russian Federation

    A. N. Proshin

Authors
  1. A. P. Orlov
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  2. T. P. Trofimova
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  3. E. Yu. Osipova
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  4. A. N. Proshin
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  5. M. A. Orlova
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Correspondence to M. A. Orlova.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1860—1866, October, 2017.

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Orlov, A.P., Trofimova, T.P., Osipova, E.Y. et al. Zinc-containing derivatives of 2-aminopyrimidine. Russ Chem Bull 66, 1860–1866 (2017). https://doi.org/10.1007/s11172-017-1958-6

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  • DOI: https://doi.org/10.1007/s11172-017-1958-6

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