Skip to main content
SpringerLink
Log in

NO-donating and hemolytic activity of tetranitrosyl iron complexes with ligands of the 2-mercaptopyridine series

  • Full Articles
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

The NO-donating and hemolytic activity of the binuclear tetranitrosyl iron complexes (TNIC) with thiolate ligands of the composition [Fe2(SR)2(NO)4], where R is pyridin-2-yl and 5-nitropyridin-2-yl, was studied. The NO-donating and hemolytic activities of the com- plex with the nitrosubstituted ligand are approximately two and three times higher than the corresponding characteristics of the complex with unsubstituted 2-mercaptopyridine, respectively. Symbate changes in these parameters confirm the conclusion made earlier on the peroxynitrite-dependent mechanism of erythrocyte hemolysis under the action of TNIC. The NO-donating activity of TNIC with ligands of the 2-mercaptopyridine series, unlike the previously studied complexes containing thioderivatives of other nitrogenous heterocycles as S-ligands, did not decrease with an increase in the concentration of erythrocytes. This allows one to consider them as promising NO-donating substances for the preparation of pharma- cological remedies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. M. Aldoshin, N. A. Sanina, in Fundamentalńye nauki — meditsine: biofizicheskie i meditsinskie tekhnologii[Fundamental Sciences for Medicine: Biophysical and Medicinal Technologies], Eds A. I. Grigoŕev, Yu. V. Vladimirov, MAKS Press, Moscow, 2015, Vol. 1, 72 (in Russian).

    Google Scholar 

  2. S. M. Aldoshin, N. A. Sanina, M. I. Davydov, E. I. Chazov, Her. Russ. Acad. Sci., 2016, 86, 158.

    Article  Google Scholar 

  3. N. A. Sanina, S. M. Aldoshin, Russ. Chem. Bull., 2004, 53, 2428.

    Article  CAS  Google Scholar 

  4. N. A. Sanina, S. M. Aldoshin, Russ. Chem. Bull., 2011, 60, 1223.

    Article  CAS  Google Scholar 

  5. N. A. Sanina, S. M. Aldoshin, N. Yu. Shmatko, D. V. Korchagin, G. V. Shilov, E. A. Knyaz´kina, N. S. Ovanesyan, A. V. Kulikov, New J. Chem., 2015, 39, 1022.

    Article  CAS  Google Scholar 

  6. N. I. Neshev, E. M. Sokolova, B. L. Psikha, N. A. Sanina, T. N. Rudneva, Russ. Chem. Bull., 2014, 63, 2020.

    Article  CAS  Google Scholar 

  7. N. I. Neshev, E. M. Sokolova, B. L. Psikha, T. N. Rudneva, N. A. Sanina, Russ. Chem. Bull., 2016, 65, 779.

    Article  CAS  Google Scholar 

  8. N. I. Neshev, B. L. Psikha, E. M. Sokolova, N. A. Sanina, T. N. Rudneva, S. V. Blokhina, Russ. Chem. Bull., 2010, 59, 2215.

    Article  CAS  Google Scholar 

  9. E. M. Sokolova, Ph. D. (Biol.) Thesis, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, 2016, 121 pp. (in Russian).

    Google Scholar 

  10. J. D. Young, L. G. Leong, M. A. DiNome, Z. A. Gohn, Anal. Biochem., 1986, 154, 649.

    Article  CAS  Google Scholar 

  11. A. Ilani, R. Granoth, BBA Biomembranes, 1990, 1027, 199.

    Article  CAS  Google Scholar 

  12. R. Lemberg, J. W. Legge, Hematin Compounds and Bile Pigments; Their Constitution, Metabolism, and Function, Interscience Publishers, New York, 1949, 748 pp.

    Google Scholar 

  13. W. G. Zijlstra, A. Buursma, W. P. Meeuwsen-van der Roest, Clin. Chem., 1991, 37, 1633.

    CAS  Google Scholar 

  14. O. A. Rakova, N. A. Sanina, G. V. Shilov, Yu. M. Shul´ga, V. M. Martynenko, N. S. Ovanesyan, S. M. Aldoshin, Russ. J. Coord. Chem., 2002, 28, 341.

    Article  CAS  Google Scholar 

  15. G. I. Kozub, N. A. Sanina, T. A. Kondratéva, G. V. Shilov, D. V. Korchagin, N. S. Ovanesyan, S. M. Aldoshin, Russ. J. Coord. Chem., 2012, 38, 671.

    Article  CAS  Google Scholar 

  16. V. Tetko, J. Gasteiger, R. Todeschini, A. Mauri, D. Livingstone, P. Ertl, V. A. Palyulin, E. V. Radchenko, N. S. Zefirov, A. S. Makarenko, V. Y. Tanchuk, V. V. Prokopenko, J. Comput. Aid. Mol. Des., 2005, 19, 453.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    N. I. Neshev, E. M. Sokolova, G. I. Kozub, T. A. Kondrat´eva & N. A. Sanina

Authors
  1. N. I. Neshev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. M. Sokolova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. I. Kozub
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. A. Kondrat´eva
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. A. Sanina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N. A. Sanina.

Additional information

Based on the Materials of the XX Mendeleev Congress on General and Applied Chemistry (September 26—30, 2016, Ekaterinburg, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1510—1514, August, 2017.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Neshev, N.I., Sokolova, E.M., Kozub, G.I. et al. NO-donating and hemolytic activity of tetranitrosyl iron complexes with ligands of the 2-mercaptopyridine series. Russ Chem Bull 66, 1510–1514 (2017). https://doi.org/10.1007/s11172-017-1916-3

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-017-1916-3

Keywords

Search

Navigation