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Synthesis and properties of quinazoline derivatives containing cymantrenyl group

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Abstract

The synthesis of new quinazoline derivatives with 2,3- and 4-positioned cymantrenyl fragment is described. Alkylation of 2-substituted quinazolin-4-ones with cymantrenylalkyl bromides on using K2CO3, potassium tert-butoxide, and sodium hydride as bases has been studied. It is established for the first time that condensation of 2-methylquinazolin-4-ones with aldehydes can cause elimination of the substituent at the nitrogen atom in position 3. The new cymantrene derivatives possess fluorescence properties.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, GSP-1, 119991, Moscow, Russian Federation

    E. S. Kelbysheva, L. N. Telegina, E. A. Ershova, T. V. Strelkova, M. G. Ezernitskaya, A. F. Smol´yakov, F. M. Dolgushin & N. M. Loim

  2. Department of Organic and Biomolecular Chemistry, B. N. Eltsin Ural Federal University, 19 ul. Mira, 620002, Ekaterinburg, Russian Federation

    E. V. Nosova

Authors
  1. E. S. Kelbysheva
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  2. L. N. Telegina
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  3. E. A. Ershova
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  4. T. V. Strelkova
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  5. M. G. Ezernitskaya
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  6. E. V. Nosova
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  7. A. F. Smol´yakov
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  8. F. M. Dolgushin
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  9. N. M. Loim
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Correspondence to N. M. Loim.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 0327—0335, February, 2017.

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Kelbysheva, E.S., Telegina, L.N., Ershova, E.A. et al. Synthesis and properties of quinazoline derivatives containing cymantrenyl group. Russ Chem Bull 66, 327–335 (2017). https://doi.org/10.1007/s11172-017-1735-6

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  • DOI: https://doi.org/10.1007/s11172-017-1735-6

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