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Synthesis of complexes of N-vinylpyrrolidone–vinylamine or N-vinylpyrrolidone–allylamine containing macrocyclic polyligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) with gallium-68 isotope and estimation of their in vivo distribution

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Abstract

A method for radiolabeling the water-soluble N-vinylpyrrolidone copolymers with N-vinyl- and N-allylamine containing bifunctional chelation unit 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetate by the radioactive isotope gallium-68 (68Ga) was developed. Radiotracers were obtained in the yield about 65%. A method of liquid chromatography for the micropreparative isolation of the metal-polymeric complexes with a radiochemical purity of ~98% was developed. The data on the stability of the complexes in blood serum and the results on the biodistribution of the synthesized complexes in organs and tissues of laboratory animals (rats) with transplantable tumor are presented.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bol´shoi prosp., 199004, St. Petersburg, Russian Federation

    N. I. Gorshkov, I. I. Gavrilova, O. V. Nazarova, A. Yu. Murko, V. D. Krasikov & E. F. Panarin

  2. Russian Scientific Center of Radiology and Surgical Technologies, Ministry of Healthcare of the Russian Federation, 70 ul. Leningradskaya, p. Pesochnyi, 197758, St. Petersburg, Russian Federation

    S. V. Shatik & A. V. Tokarev

  3. St. Petersburg State Polytechnical University, 29 ul. Politekhnicheskaya, 195251, St. Petersburg, Russian Federation

    E. F. Panarin

Authors
  1. N. I. Gorshkov
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  2. S. V. Shatik
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  3. A. V. Tokarev
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  4. I. I. Gavrilova
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  5. O. V. Nazarova
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  6. A. Yu. Murko
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  7. V. D. Krasikov
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  8. E. F. Panarin
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Corresponding author

Correspondence to N. I. Gorshkov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0156—0163, January, 2017.

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Gorshkov, N.I., Shatik, S.V., Tokarev, A.V. et al. Synthesis of complexes of N-vinylpyrrolidone–vinylamine or N-vinylpyrrolidone–allylamine containing macrocyclic polyligand 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) with gallium-68 isotope and estimation of their in vivo distribution. Russ Chem Bull 66, 156–163 (2017). https://doi.org/10.1007/s11172-017-1714-y

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  • DOI: https://doi.org/10.1007/s11172-017-1714-y

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