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Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles

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Abstract

New derivatives of the drug riluzole, 6-(trifluoromethoxy)benzothiazol-2-ylamine, modified at the endo- and exocyclic nitrogen atoms with trifluoromethyl-containing heterocycles were synthesized via transformations of methyltrifluoropyruvate and hexafluoroacetone N-6-(trifluoromethoxy)benzothiazol-2-ylimines by meams of cycloaddition and cyclocondensation reactions, respectively. The influence of the resulting compounds on neuronal NMDA receptors, as well as on the release and reuptake of the neurotransmitter glutamate was investigated.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, A. V. Sokolov, A. Gabrelian, A. D. Efimova & V. V. Grigoriev

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. A. V. Sokolov
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  4. A. Gabrelian
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  5. A. D. Efimova
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  6. V. V. Grigoriev
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Corresponding author

Correspondence to V. B. Sokolov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0099—0103, January, 2017.

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Sokolov, V.B., Aksinenko, A.Y., Sokolov, A.V. et al. Modification of biologically active amides and amines with fluorine-containing heterocycles 12.* Endo- and exocyclic modifications of the drug riluzole with trifluoromethyl-containing heterocycles. Russ Chem Bull 66, 99–103 (2017). https://doi.org/10.1007/s11172-017-1706-y

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  • DOI: https://doi.org/10.1007/s11172-017-1706-y

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