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Identification of peptides with protected functional groups by chromatography, mass spectrometry, and molecular statistics

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Abstract

The retention of peptides with protected functional groups on the Hypercarb carbon sorbent was studied by reversed phase HPLC. The peptides were identified by tandem mass spectrometry with electrospray ionization. The thermodynamic characteristics of adsorption (TCA) of the peptides on the graphitized thermal carbon black were determined by the molecular statistical method and compared with the retention values obtained by liquid chromatography on the Hypercarb carbon sorbent. Relationships between the calculated values of TCA and experimental retention values were shown.

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Authors and Affiliations

  1. A. N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Build. 4, 31 Leninsky prosp., 119071, Moscow, Russian Federation

    A. L. Milyushkin, A. A. Laktyushina & A. K. Buryak

Authors
  1. A. L. Milyushkin
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  2. A. A. Laktyushina
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  3. A. K. Buryak
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Correspondence to A. L. Milyushkin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 0056—0061, January, 2017.

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Milyushkin, A.L., Laktyushina, A.A. & Buryak, A.K. Identification of peptides with protected functional groups by chromatography, mass spectrometry, and molecular statistics. Russ Chem Bull 66, 56–61 (2017). https://doi.org/10.1007/s11172-017-1699-6

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  • DOI: https://doi.org/10.1007/s11172-017-1699-6

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