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Russian Chemical Bulletin

, Volume 65, Issue 12, pp 2952–2955 | Cite as

Synthesis of 5,4″-di-O-succinoylavermectin B1

  • E. I. Chernoburova
  • K. V. Danchenko
  • M. A. Shchetinina
  • A. A. Zharov
  • A. V. Kolobov
  • M. Kh. Dzhafarov
  • F. I. Vasilevich
  • I. V. ZavarzinEmail author
Full Articles

Abstract

A reaction of avermectin B1 with succinic anhydride at ultrahigh pressure (10 kbar) gave previously unavailable 5,4″-di-O-succinoylavermectin B1, which is of interest as potential antiparasitic agent.

Key words

ultrahigh pressure avermectin B1 succinic anhydride 5,4″-di-O-succinoylavermectin B1 acylation reaction antiparasitic activity 

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • E. I. Chernoburova
    • 1
  • K. V. Danchenko
    • 1
  • M. A. Shchetinina
    • 1
  • A. A. Zharov
    • 1
  • A. V. Kolobov
    • 2
  • M. Kh. Dzhafarov
    • 3
  • F. I. Vasilevich
    • 3
  • I. V. Zavarzin
    • 1
    Email author
  1. 1.N. D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussian Federation
  2. 2.Yaroslavl State Technical UniversityYaroslavlRussian Federation
  3. 3.K. I. Skryabin Moscow State Academy of Veterinary Medicine and BiotechnologyMoscowRussian Federation

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