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Synthesis and biological activity of N-substituted tetrahydro-γ-carbolins bearing bis(dimethylamino)phenothiazine moiety

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Abstract

An approach for modification of biologically active N-substituted tetrahydro-γ-carbolines with bis(dimethylamino)phenothiazine moiety via the CsF-catalyzed reaction of γ-carbolines with 1-[3,7-bis(dimethylamino)phenothiazin-10-yl]propenone was developed. Effects of the synthesized compounds on neuronal NMDA receptors were examined by radioligand binding assay.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    V. B. Sokolov, A. Yu. Aksinenko, T. A. Epishina, T. V. Goreva, V. V. Grigoriev, A. V. Gabrel´yan & S. O. Bachurin

Authors
  1. V. B. Sokolov
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  2. A. Yu. Aksinenko
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  3. T. A. Epishina
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  4. T. V. Goreva
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  5. V. V. Grigoriev
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  6. A. V. Gabrel´yan
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  7. S. O. Bachurin
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Corresponding author

Correspondence to V. B. Sokolov.

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Dedicated to Academician of the Russian Academy of Sciences V. I. Minkin on the occasion of his 80th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0718—0722, March, 2015.

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Sokolov, V.B., Aksinenko, A.Y., Epishina, T.A. et al. Synthesis and biological activity of N-substituted tetrahydro-γ-carbolins bearing bis(dimethylamino)phenothiazine moiety. Russ Chem Bull 64, 718–722 (2015). https://doi.org/10.1007/s11172-015-0925-3

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  • DOI: https://doi.org/10.1007/s11172-015-0925-3

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