Abstract
The effect of lipophilic [N-(3,5-di-tert-butyl-4-hydroxybenzyl)-N,N-di(2-pyridylmethyl)]-amine and its water-soluble hydrochloride on the oxidative status of tissues of Wistar rats in vivo was studied. The change in the xanthine oxidase activity, the level of free radical processes in blood, and the antioxidant activities of blood serum were determined by spectrophometry. The contents of TBA-dependent products (TBA is thiobarbituric acid) in animal tissues were measured by biochemiluminescence under induced oxidative stress conditions. The effect of [N-(3,5-di-tert-butyl-4-hydroxybenzyl)-N,N-di-(2-pyridylmethyl)]amine on organism in vivo is multi-factorial and is more pronounced for the water-soluble hydrochloride.
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Based on the materials of the First Russian Conference on Medicinal Chemistry (“MedChem Russia-2013”) with International Participation (September 8–12, 2013, Moscow).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1238–1242, May, 2014.
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Strel’nikov, A.I., Tomilova, I.K., Safronov, B.G. et al. Comparative study of in vivo impact of water-soluble and lipophilic forms of dipicolylamine containing a 2,6-di-tert-butylphenol moiety on the oxidative status of rat tissues. Russ Chem Bull 63, 1238–1242 (2014). https://doi.org/10.1007/s11172-014-0581-z
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DOI: https://doi.org/10.1007/s11172-014-0581-z