Abstract
4,5-Dihydrobenzo[g]indole and its 1-vinyl derivative were obtained from 1-tetralone, hydroxylamine, and dichloroethane in the superbasic system KOH-DMSO (140 °C, 3 h) in a total yield of 88%. The proposed method provides a fire-safe and explosion-proof approach to indole derivatives in demand.
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Dedicated to Academician of the Russian Academy of Sciences M. P. Egorov on the occasion of his 60th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2257—2258, Novemer, 2013.
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Ivanov, A.V., Barnakova, V.S., Mikhaleva, A.I. et al. The “one pot” synthesis of 4,5-dihydrobenzo[g]indole and its 1-vinyl derivative from 1-tetralone, hydroxylamine, and dichloroethane in the system KOH-DMSO. Russ Chem Bull 62, 2557–2558 (2013). https://doi.org/10.1007/s11172-013-0372-y
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DOI: https://doi.org/10.1007/s11172-013-0372-y