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Intramolecular cyclization of acetylene-containing α-amino carboxylates and α-amino phosphonates: synthesis of α-CF3-substituted dehydroprolines and their P-analogs

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Abstract

CF3-Containing α-arylpropargyl-α-amino carboxylates and α-arylpropargyl-α-amino phosphonates on treatment with the Brønsted or Lewis acids undergo cyclization involving the free NH2 group and triple bond to yield the corresponding dehydroprolines and their phosphorus analogs.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    M. A. Zotova, T. P. Vasil’eva & S. N. Osipov

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  1. M. A. Zotova
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  2. T. P. Vasil’eva
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  3. S. N. Osipov
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Correspondence to S. N. Osipov.

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Dedicated to the Academician of the Russian Academy of Sciences I. P. Beletskaya on occassion of her anniversary.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0791–0795, March, 2013.

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Zotova, M.A., Vasil’eva, T.P. & Osipov, S.N. Intramolecular cyclization of acetylene-containing α-amino carboxylates and α-amino phosphonates: synthesis of α-CF3-substituted dehydroprolines and their P-analogs. Russ Chem Bull 62, 792–796 (2013). https://doi.org/10.1007/s11172-013-0107-0

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  • DOI: https://doi.org/10.1007/s11172-013-0107-0

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