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Regioisomeric 4-amino- and 6-aminopyrazolo[3,4-b]pyridines: synthesis and structure determination by NMR spectroscopy and X-ray diffraction

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The methods for selective synthesis of regioisomeric 4-amino- and 6-amino-1-aryl-3-R-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles were developed. Heating 4-amino-substituted pyrazolo[3,4-b]pyridines gave 6-amino-substituted isomers in quantitative yield. Spectral differences characteristic of both isomers were evaluated based on the 13C NMR spectra.

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Authors and Affiliations

  1. Department of Chemistry, Saint Petersburg State University, 26 Universitetsky prosp., 198504, Saint Petersburg, Russian Federation

    A. A. Petrov, A. N. Kasatochkin & E. E. Emelina

  2. Department of Chemistry, University of Joensuu, P. O. Box 111, FI-80100, Joensuu, Finland

    M. Haukka

Authors
  1. A. A. Petrov
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  2. A. N. Kasatochkin
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  3. E. E. Emelina
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  4. M. Haukka
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Correspondence to A. A. Petrov.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0886-0991, April, 2012.

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Petrov, A.A., Kasatochkin, A.N., Emelina, E.E. et al. Regioisomeric 4-amino- and 6-aminopyrazolo[3,4-b]pyridines: synthesis and structure determination by NMR spectroscopy and X-ray diffraction. Russ Chem Bull 61, 891–896 (2012). https://doi.org/10.1007/s11172-012-0125-3

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  • DOI: https://doi.org/10.1007/s11172-012-0125-3

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