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Cytotoxic properties of the nitrosyl iron complex with phenylthiyl

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Abstract

Nitrosyl compounds based on the iron-sulfur clusters are a promising class of inorganic nitric oxide donors. We studied cytotoxic properties of one of such NO donors, viz., the nitrosyl [2Fe-2S] complex with phenyl ligands (Ph-complex). The Ph-complex induces the HeLa and H1299 tumor cell death. The Ph-complex and cisplatin used in combination exhibit synergistic cytotoxicity. During studies of the poly(ADP-ribose) polymerase degradation, it was found that the HeLa cell death induced by the Ph-complex proceeds presumably by the mechanism of apoptosis. In the MCF7 cells, the Ph-complex causes induction of p53 protein expression and changes in its apparent molecular weight.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation

    T. S. Stupina, I. I. Parkhomenko, G. V. Kostyuk, N. A. Sanina & A. A. Terent’ev

  2. N. I. Lobachevsky State University of Nizhny Novgorod, 23 prosp. Gagarina, 603950, Nizhny Novgorod, Russian Federation

    I. V. Balalaeva

Authors
  1. T. S. Stupina
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  2. I. I. Parkhomenko
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  3. I. V. Balalaeva
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  4. G. V. Kostyuk
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  5. N. A. Sanina
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  6. A. A. Terent’ev
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Correspondence to A. A. Terent’ev.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1464–1469, July, 2011.

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Stupina, T.S., Parkhomenko, I.I., Balalaeva, I.V. et al. Cytotoxic properties of the nitrosyl iron complex with phenylthiyl. Russ Chem Bull 60, 1488–1494 (2011). https://doi.org/10.1007/s11172-011-0221-9

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  • DOI: https://doi.org/10.1007/s11172-011-0221-9

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