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Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.

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Abstract

Paeciloxocins A and B (2-(1-hydroxy-3-methylbutyl)- and 2-(1-acetoxy-3-methylbutyl)- 11-hydroxy-9-methyl-1-methoxy-5H,7H-dibenzo[b,g]-1,5-dioxocin-5-ones), viz., two new metabolites, were isolated from the mangrove fungus Paecilomyces sp. collected from the Taiwan Strait. Their structures were elucidated by spectral methods. Paeciloxocin A exhibited strong cytotoxicity against the hepG2 cell line.

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Correspondence to Lu Wen.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1612-1615, August, 2010.

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Wen, L., Chen, G., She, Z. et al. Two new paeciloxocins from a mangrove endophytic fungus Paecilomyces sp.. Russ Chem Bull 59, 1656–1659 (2010). https://doi.org/10.1007/s11172-010-0290-1

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  • DOI: https://doi.org/10.1007/s11172-010-0290-1

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