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N-Substituted α-trifluoromethyl β-nitro amines in the synthesis of fluorine-containing 1,2-diamines, amino alcohols, and β-amino acids

Abstract

Reactions of 2-diazo-1,1,1-trifluoro-3-nitropropane or 1-trifluoromethyl-2-nitroethenes with amines and amino alcohols afforded N-mono- and N,N-disubstituted α-trifluoromethyl β-nitro amines, which were used to obtain a number of trifluoromethyl-containing 1,2-diamines, amino alcohols, and β-amino acids.

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Correspondence to V. Yu. Korotaev.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1827–1838, September, 2009.

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Korotaev, V.Y., Barkov, A.Y., Kodess, M.I. et al. N-Substituted α-trifluoromethyl β-nitro amines in the synthesis of fluorine-containing 1,2-diamines, amino alcohols, and β-amino acids. Russ Chem Bull 58, 1886–1898 (2009). https://doi.org/10.1007/s11172-009-0257-2

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Key words

  • diazo compounds
  • nitroalkenes
  • organofluorine compounds
  • amines
  • amino alcohols
  • β-amino acids
  • X-ray diffraction analysis