Abstract
A new class of acyclic nucleosides based on 6-phenyl-1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones was synthesized and structurally characterized for the first time.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
E. De Clercq, Nature Rev., 2002, 1, 13.
E. De Clercq, J. Antimicrob. Chemother., 2003, 51, 1079.
P. S. Jones, Antiviral Chem. Chemother., 1998, 9, 283.
E. De Clercq, Nature Rev., 2006, 5, 1015.
B. Golankiewicz, T. Ostrowski, G. Andrei, R. Snoek, E. De Clercq, J. Med. Chem., 1994, 37, 3187.
T. Goslinski, B. Golankiewicz, E. De Clercq, J. Balzarini, J. Med. Chem., 2002, 45, 5052.
T. Miyasaka, H. Tanaka, M. Bada, H. Hayakawa, R. T. Walker, J. Balzarini, E. De Clercq, J. Med. Chem., 1989, 32, 2507.
H. Tanaka, H. Takashima, M. Ubasawa, K. Sekiya, I. Nitta, M. Baba, S. Shigeta, R. T. Walker, E. De Clercq, T. Miyasaka, J. Med. Chem., 1992, 35, 4713.
W. Semaine, M. Johar, D. L. J. Tyrrell, R. Kumar, B. Agrawal, J. Med. Chem., 2006, 49, 2049.
R. Kumar, W. Semaine, M. Johar, D. L. J. Tyrrell, B. Agrawal, J. Med. Chem., 2006, 49, 3693.
F. Amblard, V. Aucagne, P. Guenot, R. F. Schinazi, L. A. Agrofoglio, Bioorg. Med. Chem., 2005, 13, 1239.
V. L. Rusinov, E. N. Ulomskii, O. N. Chupakhin, M. M. Zubairov, A. B. Kapustin, N. I. Mitin, M. I. Zhirovetskii, I. A. Vinograd, Khim.-farm. Zh., 1990, No. 9, 41 [Pharm. Chem. J., 1990, 24, No. 9, 646 (Engl. Transl.)].
Pat. RF 2294936; Chem. Abstrs., 2007, 146, 316946.
J. Farrás, E. Fos, R. Ramos, J. Vilarrasa, J. Org. Chem., 1988, 53, 887.
E. H. Ulomskii, V. L. Rusinov, O. N. Chupakhin, G. L. Rusinov, A. I. Chernyshev, G. G. Aleksandrov, Khim. Geterotsikl. Soedin., 1987, 1543 [Chem. Heterocycl. Compd., 1987, 23, 1236 (Engl. Transl.)].
C. K. Chu, S. J. Cutler, J. Heterocycl. Chem., 1986, 23, 289.
A. Larsson, S. Alenius, N.-G. Johansson, B. Oberg, Antiviral Res., 1983, 3, 77.
D. R. Borcherding, S. Narayanan, M. Hasobe, J. G. McKee, B. T. Keller, R. T. Borchardt, J. Med. Chem., 1988, 31, 1729.
S. Phadtare, D. Kessel, T. H. Corbett, H. E. Renis, B. A. Court, J. Zemlicka, J. Med. Chem., 1991, 34, 421.
H. Günther, NMR Spectroscopy an Introduction, John Wiley & Sons, Chichester, 1980, 436 pp.
F. H. Allen, O. Kennard, D. G. Watson, L. Brammer, A. G. Orpin, R. Taylor, J. Chem. Soc., Perkin Trans. 2, 1987, S1–S19.
G. M. Sheldrick, SHELXS97, Program for the Solution of Crystal Structures, Götingen University, Götingen, Germany, 1997.
G. M. Sheldrick, SHELXL97, Program for the Refinement of Crystal Structures, Göttingen University, Göttingen, Germany, 1997.
E. N. Ulomskii, S. L. Deev, T. S. Shestakova, V. L. Rusinov, O. N. Chupakhin, Izv. Akad. Nauk, Ser. Khim., 2002, 1594 [Russ. Chem. Bull., Int. Ed., 2002, 51, 1737].
M. Senkus, J. Am. Chem. Soc., 1946, 68, 734.
M. M. Smorgonskii, Ya. L. Gol’dfarb, Zh. Obshch. Khim., 1940, 10, 1113 [J. Gen. Chem. USSR, 1940, 10, 1113 (Engl. Transl.)].
Y. Kabaj, H. B. Lazrek, J. L. Barascut, J. L. Imbach, Nucleosides, Nucleotides and Nucleic Acids, 2005, 24, 161.
L. Henry, Ber., 1874, 7, 67.
Author information
Authors and Affiliations
Corresponding author
Additional information
Dedicated to Professor A. F. Pozharskii on the occasion of his 70th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2374–2380, November, 2008.
Rights and permissions
About this article
Cite this article
Shestakova, T.S., Luk’yanova, L.S., Tseitler, T.A. et al. Synthesis of acyclic nucleosides based on 1,2,4-triazolo[3,2-c][1,2,4]triazin-7-ones. Russ Chem Bull 57, 2423–2430 (2008). https://doi.org/10.1007/s11172-008-0346-7
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11172-008-0346-7