Abstract
Glycoclusters were obtained by N-alkylation of N-glycyl-β-d-galactopyranosylamine with N-chloroacetyl derivatives of β-d-galactopyranosylamine and N,N″-iminodiacetyl-di-β-d-galactopyranosylamine. The glycoclusters with two and three galactopyranosylamine residues and the monovalent ligand N-diglycyl-β-d-galactopyranosylamine with an amino group in the spacer are suitable for subsequent conjugation with carboxyl-containing physiologically active compounds.
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References
R. S. Bresalier, P.-S. Yan, J. C. Byrd, R. Lotan, A. Raz, Cancer, 1997, 80, 776.
E. V. Moiseeva, E. M. Rapoport, N. V. Bovin, A. I. Miroshnikov, A. V. Chaadaeva, M. S. Krasilschikova, V. K. Bojenko, C. Bijleveld, J. E. van Dijk, W. van der Otter, Breast Cancer Res. Treat., 2005, 91, 227.
L. M. Likhosherstov, O. S. Novikova, L. O. Kononov, V. N. Shibaev, Izv. Akad. Nauk, Ser. Khim., 2006, 1214 [Russ. Chem. Bull., Int. Ed., 2006, 55, 1262].
L. M. Likhosherstov, O. S. Novikova, G. V. Mokrov, Izv. Akad. Nauk, Ser. Khim., 2008, 647 [Russ. Chem. Bull., Int. Ed., 2008, 57, 660].
L. M. Likhosherstov, O. S. Novikova, L. O. Kononov, A. V. Orlova, I. B. Sivaev, V. I. Bregadze, Izv. Akad. Nauk, Ser. Khim., 2007, 2033 [Russ. Chem. Bull., Int. Ed., 2007, 56, 2105].
L. M. Likhosherstov, O. S. Novikova, A. O. Zheltova, V. N. Shibaev, Izv. Akad. Nauk, Ser. Khim., 2000, 1461 [Russ. Chem. Bull., 2000, 49, 1454 (Engl. Transl.)].
L. M. Likhosherstov, O. S. Novikova, V. N. Shibaev, Dokl. Akad. Nauk, 2002, 383, 500 [Dokl. Chem., 2002, 383, 89 (Engl. Transl.)].
G. Magnusson, A. Ya. Chernyak, J. Kihlberg, L. O. Kononov, in Neoglycoconjugates: Preparation and Application, Eds Y. C. Lee, R. T. Lee, Academic Press Inc., San Diego, California, 1994, p. 53.
L. M. Likhosherstov, O. S. Novikova, V. N. Shibaev, N. K. Kochetkov, Izv. Akad. Nauk, Ser. Khim., 1996, 1848 [Russ. Chem. Bull., 1996, 45, 1760 (Engl. Transl.)].
U. K. Saha, R. Roy, Tetrahedron Lett., 1997, 38, 7697.
A. I. Usov, M. A. Rekhter, Zh. Obshch. Khim., 1969, 39, 912 [J. Gen. Chem. USSR, 1969, 39 (Engl. Transl.)].
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2369–2373, November, 2008.
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Likhosherstov, L.M., Novikova, O.S. & Mokrov, G.V. Synthesis of β-d-galactopyranosylamine derivatives with the terminal amino group in the spacer as mono-, di-, and trivalent ligands of galectins. Russ Chem Bull 57, 2418–2422 (2008). https://doi.org/10.1007/s11172-008-0345-8
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DOI: https://doi.org/10.1007/s11172-008-0345-8