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5-Hydroxy-6-methyluracil as an efficient scavenger of peroxy radicals

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Abstract

The reaction of 5-hydroxy-6-methyluracil with peroxy radicals generated by the thermal decomposition of azodiisobutyronitrile was studied at 75 °C in ethanol, propan-2-ol, and dimethyl sulfoxide. The stoichiometry of the reaction is 1: 1. The reaction product is dihydro-6-hydroxy-6-methylpyrimidine-2,4,5-trione in an anhydrous solvent or dihydro-5,5,6-trihy-droxy-6-methylpyrimidine-2,4-dione in the presence of water. The rate constant for the reaction of 5-hydroxy-6-methyluracil with the peroxy radicals is ∼108 L mol−1 s−1.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian Federation

    N. N. Kabalnova, S. A. Grabovskiy, T. R. Nugumanov, S. P. Ivanov & Yu. I. Murinov

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  1. N. N. Kabalnova
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  2. S. A. Grabovskiy
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  3. T. R. Nugumanov
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  4. S. P. Ivanov
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  5. Yu. I. Murinov
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Correspondence to N. N. Kabalnova.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2223–2227, November, 2008.

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Kabalnova, N.N., Grabovskiy, S.A., Nugumanov, T.R. et al. 5-Hydroxy-6-methyluracil as an efficient scavenger of peroxy radicals. Russ Chem Bull 57, 2265–2270 (2008). https://doi.org/10.1007/s11172-008-0318-y

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  • DOI: https://doi.org/10.1007/s11172-008-0318-y

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