Skip to main content
SpringerLink
Log in

Simulation of interactions between DNA and diglycerides

  • Full Articles
  • Published:
Russian Chemical Bulletin Aims and scope

Abstract

Calculations by molecular mechanics methods showed that diglycerides containing stearic, oleic, linoleic, or linolenic acids can bind to DNA. The binding energy of diglycerides to the DNA minor groove is higher than that to the major groove. The bond energies of diglycerides to DNA were calculated as the sums of the contributions of the binding energies between DNA and two fatty acid residues. These energies depend on the structure of the fatty acid and the nucleotide composition of DNA and vary from 20 to 120 kcal mol−1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. V. A. Struchkov, E. P. Dyachkov, N. B. Strazhevskaya, R. I. Zhdanov, P. N. Dyachkov, Dokl. Akad. Nauk, 2001, 381, 554 [Dokl. Chem., 2001 (Engl. Transl.)].

    CAS  Google Scholar 

  2. R. I. Zhdanov, E. P. Dyachkov, N. B. Strazhevskaya, V. A. Struchkov, P. N. Dyachkov, Dokl. Akad. Nauk, 2003, 390, 548 [Dokl. Chem., 2003 (Engl. Transl.)].

    Google Scholar 

  3. R. I. Zhdanov, E. P. Dyachkov, N. B. Strazhevskaya, V. A. Struchkov, P. N. Dyachkov, Izv. Akad. Nauk, Ser. Khim., 2003, 1794 [Russ. Chem. Bull., Int. Ed., 2003, 52, 1893].

    Google Scholar 

  4. R. I. Zhdanov, E. P. Dyachkov, N. B. Strazhevskaya, A. S. Krylov, A. S. Shmyrina, P. N. Dyachkov, V. Lorents, A. A. Kubatiev, Izv. Akad. Nauk, Ser. Khim., 2005, 54, 2138 [Russ. Chem. Bull., Int. Ed., 2005, 54, 2204].

    Google Scholar 

  5. B. B. Fedorov, P. N. Dyachkov, R. I. Zhdanov, Izv. Akad. Nauk, Ser. Khim., 1999, 48. 2068 [Russ. Chem. Bull., 1999, 48, 2046 (Engl. Transl.)].

    Google Scholar 

  6. P. N. Dyachkov, B. B. Fedorov, G. Bischoff, R. Bischoff, R. I. Zhdanov, Bioelectrochem., 2002, 58, 47.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, 24 Kashirskoe sh., 115478, Moscow, Russian Federation

    N. I. Boiko

  2. Yeditepe University, 26 Agustos Yerlesimi st., 34755, Istanbul, Turkey

    R. I. Zhdanov

  3. N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 31 Leninsky prosp., 119991, Moscow, Russian Federation

    E. P. Dyachkov & P. N. Dyachkov

Authors
  1. N. I. Boiko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. I. Zhdanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. P. Dyachkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. N. Dyachkov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. N. Dyachkov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1741–1744, August, 2008.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Boiko, N.I., Zhdanov, R.I., Dyachkov, E.P. et al. Simulation of interactions between DNA and diglycerides. Russ Chem Bull 57, 1775–1778 (2008). https://doi.org/10.1007/s11172-008-0236-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11172-008-0236-z

Key words

Search

Navigation