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Simple synthesis of new chiral oxindole derivative

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Abstract

A synthesis of chiral optically active 3-hydroxyoxindoles with 1,3-disubstituted 2,2-dimethyl-cyclobutane structural fragment by the Et2NH-catalyzed aldol reaction of indoline-2,3-diones with (−)-(1S,3S)-pinonic acid derivatives is described.

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Authors and Affiliations

  1. Institute of Chemistry, Academy of Sciences of Moldova Republic, 3 ul. Akademiei, MD-2028, Kishinev, Moldova Republic

    F. Z. Makaev, O. M. Radul & A. P. Gudima

Authors
  1. F. Z. Makaev
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  2. O. M. Radul
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  3. A. P. Gudima
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Correspondence to F. Z. Makaev.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1540–1543, July, 2008.

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Makaev, F.Z., Radul, O.M. & Gudima, A.P. Simple synthesis of new chiral oxindole derivative. Russ Chem Bull 57, 1571–1574 (2008). https://doi.org/10.1007/s11172-008-0204-7

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  • DOI: https://doi.org/10.1007/s11172-008-0204-7

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