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Biologically active metabolites of the actinobacterium Streptomyces sp. GW 33/1593

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Abstract

A new cyclic dipeptide, 3-a[(4-hydroxybenzyl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione (1) together with the known compounds, 2,3-dihydroxybenzoic acid (2), and 6-(3-methylbut-2-enyl)isatin (3) were isolated from the actinobacterium Streptomyces sp. GW 33/1593. Compounds 1 and 2 possessed cytotoxic activity against the sea urchin Strongylocentrotus intermedius embryos.

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Authors and Affiliations

  1. Pacific Institute of Bioorganic Chemistry, Far-East Branch of the Russian Academy of Sciences, 159 pr. 100-let Vladivostoka 159, 690022, Vladivostok, Russian Federation

    M. P. Sobolevskaya, V. A. Denisenko, N. I. Menzorova, Yu. T. Sibirtsev & T. A. Kuznetsova

  2. Department of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077, Göttingen, Germany

    S. Fotso & H. Laach

Authors
  1. M. P. Sobolevskaya
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  2. V. A. Denisenko
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  3. S. Fotso
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  4. H. Laach
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  5. N. I. Menzorova
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  6. Yu. T. Sibirtsev
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  7. T. A. Kuznetsova
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Corresponding author

Correspondence to T. A. Kuznetsova.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 652–655, March, 2008.

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Sobolevskaya, M.P., Denisenko, V.A., Fotso, S. et al. Biologically active metabolites of the actinobacterium Streptomyces sp. GW 33/1593. Russ Chem Bull 57, 665–668 (2008). https://doi.org/10.1007/s11172-008-0105-9

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  • DOI: https://doi.org/10.1007/s11172-008-0105-9

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