Abstract
Heating of 3-nitro-2-trifluoromethyl-and 3-nitro-2-trichloromethyl-2H-chromenes with indole, N-methylindole, and N-methylpyrrole under solvent-free conditions led with high stereoselectivity and in good yields to cis-trans-3-nitro-2-trifluoromethyl-or trans-cis-3-nitro-2-trichloromethylchromanes substituted by the indol-3-yl (pyrrol-2-yl) fragment in position 4.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1985–1990, October, 2007.
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Korotaev, V.Y., Sosnovskikh, V.Y. & Kutyashev, I.B. Reactions of 3-nitro-2-trihalomethyl-2H-chromenes with indole, N-methylindole, and N-methylpyrrole. Stereoselective synthesis of 4-azolyl-3-nitro-2-trihalomethylchromanes. Russ Chem Bull 56, 2054–2059 (2007). https://doi.org/10.1007/s11172-007-0321-8
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DOI: https://doi.org/10.1007/s11172-007-0321-8