Abstract
Derivatives of 2-alkyl-2-mercaptopropionic acid were synthesized based on the substituted 3-cyanopyridin-2(1H)-thiones. The synthesis was carried out by the heating of a mixture of thione, alkyl methyl ketone, and chloroform in the presence of a base. The reaction proceeds readily for acetone, whereas alkyl methyl ketones require a prolonged heating in the presence of a phase-transfer catalyst. Methyl esters were prepared from the acids obtained.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1967–1970, October, 2007.
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Zav’alova, V.K., Zubarev, A.A. & Litvinov, V.P. Synthesis of 2-alkyl-2-(3-cyanopyridin-2-ylthio)propionic acids. Russ Chem Bull 56, 2034–2037 (2007). https://doi.org/10.1007/s11172-007-0317-4
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DOI: https://doi.org/10.1007/s11172-007-0317-4